A biomarker of plasma signaling proteins that predicts clinical Alzheimer's diagnosis.
| PAG Title | A biomarker of plasma signaling proteins that predicts clinical Alzheimer's diagnosis. |
| PAG ID | MAX002388 |
| Type | A |
| Source Link |  MSigDB |
| Publication Reference | NA |
| PAG Description | A molecular test for Alzheimer's disease could lead to better treatment and therapies. We found 18 signaling proteins in blood plasma that can be used to classify blinded samples from Alzheimer's and control subjects with close to 90% accuracy and to identify patients who had mild cognitive impairment that progressed to Alzheimer's disease 2-6 years later. Biological analysis of the 18 proteins points to systemic dysregulation of hematopoiesis, immune responses, apoptosis and neuronal support in presymptomatic Alzheimer's disease. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 253 |
| Information Content | Rich |
| Other IDs | M11893 |
| Base PAG ID | MAX002388 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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